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Article

HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.

Human immunology - 1 Oct 1993

Serjeantson S W, Court J, Mackay I R, Matheson B, Rowley M J, Tuomi T, Wilson J D, Zimmet P

Abstract excerpt

This study has investigated the genetic basis of the heterogeneous autoimmune response to glutamic acid decarboxylase (GAD) in 179 Australian patients with IDDM. Antibodies to GAD have been correlated with HLA-DQB1 alleles and genotypes, as determined by sequence-specific oligonucleotide hybridiz...

Topics

Adolescent
Age of Onset
Autoantibodies
Autoimmunity
Child
Diabetes Mellitus, Type 1
Genotype
Glutamate Decarboxylase
HLA-DQ Antigens
Humans
Polymerase Chain Reaction
Precipitin Tests

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Identifiers

PMID: 8106272
DOI: 10.1016/0198-8859(93)90525-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8106272-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.PMID 8106272Read ↗

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.Semantic proximity Read ↗

HLA Class I Haplotype in Glutamic Acid Decarboxylase Antibody-Associated Neurological Disease.Semantic proximity Read ↗

Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group.Semantic proximity Read ↗

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.Semantic proximity Read ↗

Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.Semantic proximity Read ↗

Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM.Semantic proximity Read ↗

Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes.Semantic proximity Read ↗

Class II HLA genotype in fulminant type 1 diabetes: A nationwide survey with reference to glutamic acid decarboxylase antibodiesSemantic proximity Read ↗

Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus.Semantic proximity Read ↗

Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes.Semantic proximity Read ↗

HLA genes associated with autoimmunity and progression to disease in type 1 diabetes.Semantic proximity Read ↗

Glutamic acid decarboxylase 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and haplotypes in type 1 diabetes mellitus.Semantic proximity Read ↗

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