Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11.

Abstract excerpt

Using gene targeting, we have created mice with a disruption in the homeobox-containing gene hoxd-11. Homozygous mutants are viable and the only outwardly apparent abnormality is male infertility. Skeletons of mutant mice show a homeotic transformation that repatterns the sacrum such that each ve...

Topics

• Animals
• Bone and Bones
• Genes, Homeobox
• In Situ Hybridization
• Limb Deformities, Congenital
• Mice
• Mice, Transgenic
• Mutagenesis, Site-Directed
• Mutation
• Phenotype
• Transformation, Genetic