Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.

doi:10.1128/mcb.14.1.21-31.1994

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.

Molecular and cellular biology - 1 Jan 1994

Singh N, Zoeller R A, Tykocinski M L, Lazarow P B, Tartakoff A M

Abstract excerpt

A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the synthesis of base-resistant lipid components of glycosylphosphoinositol (GPI)-anchored membrane proteins, we have investigated the structure of anchor precursor mannolipids both in wild-type cells (CHO-K1 and a...

Topics

Alkaline Phosphatase
Animals
CHO Cells
Cell Line
Cell Membrane
Cricetinae
Diglycerides
Glycosylphosphatidylinositols
Humans
Lipid Metabolism
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Microbodies

Models, Biological

Mutation

Rabbits

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 8264589
DOI: 10.1128/mcb.14.1.21-31.1994
PMCID: PMC358352

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.PMID 8264589Read ↗

Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum.Semantic proximity Read ↗

CHO glycosylation mutants: GPI anchor.Semantic proximity Read ↗

Class F Thy-1-negative murine lymphoma cells are deficient in ether lipid biosynthesis.Semantic proximity Read ↗

Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor.Semantic proximity Read ↗

Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis.Semantic proximity Read ↗

Biochemical analysis of glycophospholipids from wild-type mouse lymphoma cells and from Thy-1 negative mutants which do not add glycolipid-anchored proteins.Semantic proximity Read ↗

Two different mutants blocked in synthesis of dolichol-phosphoryl-mannose do not add glycophospholipid anchors to membrane proteins: quantitative correction of the phenotype of a CHO cell mutant with tunicamycin.Semantic proximity Read ↗

Biosynthesis of glycophosphoinositol anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.Semantic proximity Read ↗

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways.Semantic proximity Read ↗

Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome. Peroxisome-to-endoplasmic reticulum translocation of a phospholipase C.Semantic proximity Read ↗

Biosynthesis of the side chain of yeast glycosylphosphatidylinositol anchors is operated by novel mannosyltransferases located in the endoplasmic reticulum and the Golgi apparatus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.