Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1997

Romagnoli P, Bron C

Abstract excerpt

Previous reports suggested that T lymphocyte activation through phosphatidylinositol-based glycolipid (GPI)-anchored molecules is dependent on surface expression of the TCR. Here we show that stimulation of the TCR in five mutant cell lines with deficiencies in GPI biosynthesis fails to induce tyrosine phosphorylation of the TCR zeta-chain and ZAP-70, indicating that early events in TCR-mediated signal...

Topics

Cell Line
Glycosylphosphatidylinositols
Humans
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Mutation
Neoplasm Proteins
Phosphorylation
Protein-Tyrosine Kinases
Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, gamma-delta
Signal Transduction
Tyrosine
ZAP-70 Protein-Tyrosine Kinase
src-Family Kinases

Source

Open in PubMed

Identifiers

PMID: 9190926

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics