Article
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.
Genomics - 1 Jul 1993
Shoffner J M, Brown M D, Torroni A, Lott M T, Cabell M F, Mirra S S, Beal M F, Yang C C, Gearing M, Salvo R
Abstract excerpt
Mitochondrial DNA (mtDNA) variants associated with Alzheimer disease (AD) and Parkinson disease (PD) were sought by restriction endonuclease analysis in a cohort of 71 late-onset Caucasian patients. A tRNA(Gln) gene variant at nucleotide pair (np) 4336 that altered a moderately conserved nucleoti...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Animal Population Groups
- Animals
- Base Sequence
- Cohort Studies
- DNA Mutational Analysis
- DNA, Mitochondrial
- DNA, Ribosomal
- Female
- Genetic Variation
- Humans
- Male
- Middle Aged
- Molecular Sequence Data