Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.

Genomics - 1 Jul 1993

Shoffner J M, Brown M D, Torroni A, Lott M T, Cabell M F, Mirra S S, Beal M F, Yang C C, Gearing M, Salvo R

Abstract excerpt

Mitochondrial DNA (mtDNA) variants associated with Alzheimer disease (AD) and Parkinson disease (PD) were sought by restriction endonuclease analysis in a cohort of 71 late-onset Caucasian patients. A tRNA(Gln) gene variant at nucleotide pair (np) 4336 that altered a moderately conserved nucleotide was present in 9/173 (5.2%) of the patients surveyed but in only 0.7% of the general Caucasian controls. One of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to DNA, Mitochondrial

Share to DNA Mutational Analysis

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8104867
DOI: 10.1006/geno.1993.1299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.PMID 8104867Read ↗

Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients.Semantic proximity Read ↗

Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease.Semantic proximity Read ↗

Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases.Semantic proximity Read ↗

Mitochondrial DNA A4336G mutation in Alzheimer's and Parkinson's diseases.Semantic proximity Read ↗

Mitochondrial DNA variants in a portuguese population of patients with Alzheimer's disease.Semantic proximity Read ↗

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.Semantic proximity Read ↗

No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant.Semantic proximity Read ↗

Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer’s disease neurodegenerationSemantic proximity Read ↗

Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population.Semantic proximity Read ↗

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort.Semantic proximity Read ↗

No consistent evidence for association between mtDNA variants and Alzheimer disease.Semantic proximity Read ↗

Genetic basis of Alzheimer's dementia: role of mtDNA mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.