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Article

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort.

Neurobiology of aging - 1 Aug 2010

Lakatos Anita, Derbeneva Olga, Younes Danny, Keator David, Bakken Trygve, Lvova Maria, Brandon Marty, Guffanti Guia, Reglodi Dora, Saykin Andrew, Weiner Michael, Macciardi Fabio, Schork Nicholas, Wallace Douglas C, Potkin Steven G

Abstract excerpt

Despite the central role of amyloid deposition in the development of Alzheimer's disease (AD), the pathogenesis of AD still remains elusive at the molecular level. Increasing evidence suggests that compromised mitochondrial function contributes to the aging process and thus may increase the risk of AD. Dysfunctional mitochondria contribute to reactive oxygen species (ROS) which can lead to extensive macromolecule...

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Identifiers

PMID: 20538375
DOI: 10.1016/j.neurobiolaging.2010.04.031
PMCID: PMC2918801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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