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Article

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995

Hutchin T, Cortopassi G

Abstract excerpt

Severe mitochondrial genetic mutations lead to early degeneration of specific human tissues; milder mitochondrial mutations may cause degeneration at a later point in life. A mutation at position 4336 was reported to occur at increased frequency in individuals with Alzheimer disease (AD) and Parkinson disease [Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang,...

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Identifiers

PMID: 7624338
DOI: 10.1073/pnas.92.15.6892
PMCID: PMC41436

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