A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

doi:10.1073/pnas.92.15.6892

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Article

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995

Hutchin T, Cortopassi G

Abstract excerpt

Severe mitochondrial genetic mutations lead to early degeneration of specific human tissues; milder mitochondrial mutations may cause degeneration at a later point in life. A mutation at position 4336 was reported to occur at increased frequency in individuals with Alzheimer disease (AD) and Park...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Autopsy
Case-Control Studies
DNA, Mitochondrial
Humans
Mitochondria
Models, Genetic
Mutation
Phylogeny
Polymerase Chain Reaction
RNA, Transfer, Gly
Risk Factors
White People

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