Article
Mitochondrial DNA variants in a portuguese population of patients with Alzheimer's disease.
European neurology - 1 Jan 2005
Grazina Manuela, Silva Filipe, Santana Isabel, Pratas João, Santiago Beatriz, Oliveira Miguel, Carreira Isabel, Cunha Luís, Oliveira Catarina
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with dementia in late adulthood. Mitochondrial respiratory chain impairment has been detected in the brain, muscle, fibroblasts and platelets of AD patients, indicating a possible involvement of mitochondrial DNA (mtDNA) in the etiology of the disease. Several reports have identified mtDNA mutations in AD patients, but there is no...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
