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Article

No consistent evidence for association between mtDNA variants and Alzheimer disease.

Neurology - 3 Apr 2012

Hudson G, Sims R, Harold D, Chapman J, Hollingworth P, Gerrish A, Russo G, Hamshere M, Moskvina V, Jones N, Thomas C, Stretton A, Holmans P A, O'Donovan M C, Owen M J, Williams J, Chinnery P F

Abstract excerpt

OBJECTIVE: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. METHODS: We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian...

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Identifiers

PMID: 22442439
DOI: 10.1212/WNL.0b013e31824e8f1d
PMCID: PMC3317529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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