Article
Genetic basis of Alzheimer's dementia: role of mtDNA mutations.
Genes, brain, and behavior - 1 Jan 2006
Grazina M, Pratas J, Silva F, Oliveira S, Santana I, Oliveira C
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated to dementia in late adulthood. Amyloid precursor protein, presenilin 1 and presenilin 2 genes have been identified as causative genes for familial AD, whereas apolipoprotein E epsilon4 allele has been associated to the risk for late onset AD. However, mutations on these genes do not explain the majority of cases. Mitochondrial...
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