Article
No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant.
Neuroscience letters - 8 Dec 1995
Wragg M A, Talbot C J, Morris J C, Lendon C L, Goate A M
Abstract excerpt
We have screened a large sample of patients with sporadic late-onset dementia of the Alzheimer type (DAT) and age-matched controls for a mitochondrial tRNA(Gln) variant previously reported to be associated with increased risk of developing Alzheimer's disease (AD). The frequency of an Ava II site...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Base Sequence
- DNA
- DNA, Mitochondrial
- Humans
- Mitochondria
- Molecular Sequence Data
- Oxidative Phosphorylation
- Polymerase Chain Reaction
- RNA, Transfer, Gln