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Article

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

Lancet (London, England) - 12 Aug 1995

Clausen J O, Hansen T, Bjørbaek C, Echwald S M, Urhammer S A, Rasmussen S, Andersen C B, Hansen L, Almind K, Winther K

Abstract excerpt

We previously discovered two aminoacid polymorphisms in codons 513 and 972 of the protein insulin receptor substrate-1 (IRS-1), which is important in cellular insulin action. We have investigated whether these polymorphisms are associated with changes in insulin sensitivity in a random sample of young healthy adults. Insulin sensitivity and secretion were measured during a combined intravenous glucose and...

Topics

Adolescent
Adult
Codon
Dexamethasone
Female
Glucose Tolerance Test
Heterozygote
Humans
Insulin Receptor Substrate Proteins
Insulin Resistance
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Obesity

Phosphoproteins

Polymorphism, Genetic

Tolbutamide

Source

Identifiers

PMID: 7623569
DOI: 10.1016/s0140-6736(95)92779-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7623569-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.PMID 7623569Read ↗

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