Article
The CYP1A1 gene and cancer susceptibility.
Critical reviews in oncology/hematology - 1 Feb 1993
Kawajiri K, Nakachi K, Imai K, Watanabe J, Hayashi S
Abstract excerpt
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A...
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