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CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation.

Cancer causes & control : CCC - 1 May 2005

Ng Daniel P K, Tan Kar-Wai, Zhao Bin, Seow Adeline

Abstract excerpt

OBJECTIVE: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women. METHODS: A total of 126 incident lung cancer cases, of which 87.7 were pathologically confirmed, and 162 age-matched hospital controls were included. CYP1A1 MspI and Ile(462)Val...

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Identifiers

PMID: 15953982
DOI: 10.1007/s10552-004-5476-0

Genes

GSTM1

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