Article
The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies.
Mutagenesis - 1 May 2011
Chen Zhiwei, Li Ziming, Niu Xiaomin, Ye Xiangyun, Yu Yongfeng, Lu Shun, Chen Zhen
Abstract excerpt
The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. In the past decade, the relationship between CYP1A1 and lung cancer has been reported...
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