Article
Lung cancer, race, and a CYP1A1 genetic polymorphism.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Shields P G, Caporaso N E, Falk R T, Sugimura H, Trivers G E, Trump B F, Hoover R N, Weston A, Harris C C
Abstract excerpt
The assessment of human cancer risk using molecular epidemiological techniques involves determining the relative contributions of inherited and acquired genetic predispositions, in the context of environmental exposures. Recently described genetic polymorphisms for CYP1A1, a gene involved in the metabolic activation of polycyclic aromatic hydrocarbons, have been associated with lung cancer risk in a Japanese...
Topics
- Asthma
- Black People
- Blotting, Southern
- Case-Control Studies
- Cytochrome P-450 Enzyme System
- DNA, Neoplasm
- Gene Frequency
- Genotype
- Heterozygote
- Homozygote