Article
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Cancer research - 1 Jul 1993
Nakachi K, Imai K, Hayashi S, Kawajiri K
Abstract excerpt
An association of lung cancer susceptibility with an MspI restriction site polymorphism of the CYP1A1 gene was reported in our previous study. This polymorphism has been subsequently found to be closely linked to another isoleucine-valine (Ile-Val) polymorphism, which resulted in an Ile-Val amino...
Topics
- Adult
- Aged
- Carcinogens
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytochrome P-450 Enzyme System
- DNA-Cytosine Methylases
- Disease Susceptibility
- Dose-Response Relationship, Drug
- Environmental Exposure
- Enzyme Activation
- Female
- Genotype
- Glutathione Transferase
- Humans
- Inactivation, Metabolic
- Isoleucine
- Japan