Article
Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility.
Pharmacogenetics - 1 Jan 1995
Kawajiri K, Watanabe J, Eguchi H, Hayashi S
Abstract excerpt
A close association of smoking-associated lung cancer incidence with the Msp 1 and 1le-Val polymorphisms of CYP1A1 gene was found in a Japanese population in terms of genotype frequency comparison and cigarette dose response. A synergistic increase in susceptibility to lung cancer was observed wh...
Topics
- Chromosome Aberrations
- Cytochrome P-450 Enzyme System
- Deoxyribonuclease HpaII
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Isoleucine
- Lung Neoplasms
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length