Article
Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans.
Carcinogenesis - 1 Aug 1993
Bell D A, Taylor J A, Butler M A, Stephens E A, Wiest J, Brubaker L H, Kadlubar F F, Lucier G W
Abstract excerpt
Carcinogenic arylamines are acetylated by the hepatic N-acetyltransferase. This enzyme is polymorphic in humans and in some epidemiological studies, the slow-acetylator phenotype has been associated with higher risk of bladder cancer and lower risk of colorectal cancer. The presence of two germli...
Topics
- Acetylation
- Alleles
- Amino Acid Sequence
- Arylamine N-Acetyltransferase
- Base Sequence
- Black People
- Caffeine
- Genotype
- Humans
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Sequence Homology, Amino Acid