Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis.

doi:10.3109/08916939309079237

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Article

Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis.

Autoimmunity - 1 Jan 1993

Leung P S, Watanabe Y, Munoz S, Teuber S S, Patel M S, Korenberg J R, Hara P, Coppel R, Gershwin M E

Abstract excerpt

Patients with primary biliary cirrhosis are well known for the presence of titer antibodies against dihydrolipoamide acetyltransferase, the E2 subunit of the pyruvate dehydrogenase complex. We have taken advantage of a cDNA probe for dihydrolipoamide acetyltransferase to explore the possibility o...

Topics

Autoantigens
Chromosome Mapping
Chromosomes, Human, Pair 11
Genotype
Humans
Liver Cirrhosis, Biliary
Polymorphism, Restriction Fragment Length
Pyruvate Dehydrogenase Complex

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