Article
Defining the immunogenetic susceptibility to primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Nov 1994
Mehal W Z, Gregory W L, Lo Y M, Cross S J, Fleming K A, Bassendine M F, James O F, Campbell R D, Chapman R W, Rosenberg W M
Abstract excerpt
Primary biliary cirrhosis is a chronic cholestatic disease, thought to be immune-mediated with genetic susceptibility encoded in the major histocompatibility complex. In northern Europeans, the best established associations are with HLA-DR8 and the complement allele, C4B2. These associations coul...
Topics
- Alleles
- Base Sequence
- Complement System Proteins
- Cosmids
- Disease Susceptibility
- Genetic Predisposition to Disease
- Genotype
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Haplotypes
- Humans
- Immunogenetics
- Liver Cirrhosis, Biliary
- Molecular Probes
- Molecular Sequence Data
- Reference Values