Article
Defining the immunogenetic susceptibility to primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Nov 1994
Mehal W Z, Gregory W L, Lo Y M, Cross S J, Fleming K A, Bassendine M F, James O F, Campbell R D, Chapman R W, Rosenberg W M
Abstract excerpt
Primary biliary cirrhosis is a chronic cholestatic disease, thought to be immune-mediated with genetic susceptibility encoded in the major histocompatibility complex. In northern Europeans, the best established associations are with HLA-DR8 and the complement allele, C4B2. These associations could be due to a single susceptibility locus on an extended haplotype linking HLA-DR8 and C4B2 or to both HLA-DR8 and C4B2...
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