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Article

Immunogenetic analysis reveals that epitope shifting occurs during B-cell affinity maturation in primary biliary cirrhosis.

Journal of molecular biology - 9 Feb 2001

Potter K N, Thomson R K, Hamblin A, Richards S D, Lindsay J G, Stevenson F K

Abstract excerpt

Primary biliary cirrhosis (PBC) is a liver disease characterized by serum autoantibodies against the pyruvate dehydrogenase complex (PDC) located in the inner mitochondrial membrane. The predominant target in PDC has previously been localized to the inner lipoyl domain (ILD) of the E2 subunit. The etiology of PBC is unknown, although molecular mimicry with bacterial PDC has been proposed. Here, we have...

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Share to Antibody Specificity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Immunoglobulin Fab Fragments

Share to Immunoglobulin Light Chains

Share to Liver Cirrhosis, Biliary

Share to Pyruvate Dehydrogenase Complex

Source

Identifiers

PMID: 11178892
DOI: 10.1006/jmbi.2000.4210

Genes

PDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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