Article
Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Nov 2002
Matsumura Shuji, Kita Hiroto, He Xiao-Song, Ansari Aftab A, Lian Zhe-Xiong, Van De Water Judy, Yamamoto Kazuhide, Tsuji Takao, Coppel Ross L, Kaplan Marshall, Gershwin M Eric
Abstract excerpt
Growing evidence has implicated the involvement of autoreactive T lymphocytes in the pathogenesis of primary biliary cirrhosis (PBC). We have recently taken advantage of motif prediction analysis of HLA-A*0201 and identified the first major histocompatibility complex (MHC) class I restricted epitope, amino acids 159 to 167 on E2 components of pyruvate dehydrogenase complexes (PDC-E2), the major mitochondrial...
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