Article
The human pyruvate dehydrogenase complex: a polymorphic region of the lipoate acetyl transferase (E2) subunit gene.
Biochimica et biophysica acta - 23 Sept 1991
Moehario L H, Wang L, Devenish R J, Mackay I R, Marzuki S
Abstract excerpt
A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. cDNA clones spanning a segment of the 3'-catalytic region of PDH-E2 (nt...
Topics
- Acetyltransferases
- Aged
- Amino Acid Sequence
- Base Sequence
- Bile Ducts
- Cloning, Molecular
- Dihydrolipoyllysine-Residue Acetyltransferase
- Epithelium
- Female
- Genetic Variation
- Humans
- Isoenzymes
- Kidney
- Liver Cirrhosis, Biliary
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Placenta
- Polymerase Chain Reaction