Article
Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.
The Journal of experimental medicine - 1 Feb 1995
Van de Water J, Ansari A, Prindiville T, Coppel R L, Ricalton N, Kotzin B L, Liu S, Roche T E, Krams S M, Munoz S, Gershwin M E
Abstract excerpt
The extraordinary specificity of bile duct destruction in primary biliary cirrhosis (PBC) and the presence of T cell infiltrates in the portal tracts have suggested that biliary epithelial cells are the targets of an autoimmune response. The immunodominant antimitochondrial response in patients w...
Topics
- Adult
- Aged
- Autoimmunity
- Clone Cells
- Female
- Humans
- Liver
- Liver Cirrhosis, Biliary
- Middle Aged
- Mitochondria, Liver
- Monocytes
- Phenotype
- Pyruvate Dehydrogenase Complex
- Receptors, Antigen, T-Cell