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Article

Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.

The Journal of experimental medicine - 1 Feb 1995

Van de Water J, Ansari A, Prindiville T, Coppel R L, Ricalton N, Kotzin B L, Liu S, Roche T E, Krams S M, Munoz S, Gershwin M E

Abstract excerpt

The extraordinary specificity of bile duct destruction in primary biliary cirrhosis (PBC) and the presence of T cell infiltrates in the portal tracts have suggested that biliary epithelial cells are the targets of an autoimmune response. The immunodominant antimitochondrial response in patients with PBC is directed against the E2 component of pyruvate dehydrogenase (PDC-E2). Hitherto, there have only been limited...

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Identifiers

PMID: 7836925
DOI: 10.1084/jem.181.2.723
PMCID: PMC2191887

Genes

PDC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.PMID 7836925Read ↗

Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosisSemantic proximity Read ↗

HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.Semantic proximity Read ↗

Autoreactive liver-infiltrating T cells in primary biliary cirrhosis recognize inner mitochondrial epitopes and the pyruvate dehydrogenase complex.Semantic proximity Read ↗

Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis.Semantic proximity Read ↗

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis.Semantic proximity Read ↗

Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.Semantic proximity Read ↗

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Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology.Semantic proximity Read ↗

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