Article
Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Sept 1994
Cha S, Leung P S, Coppel R L, Van de Water J, Ansari A A, Gershwin M E
Abstract excerpt
The polyclonal nature of antimitochondrial autoantibodies and the limited success of generating human monoclonal antibodies have made analysis of fine specificity and antibody heterogeneity difficult to define. The major autoantigen of primary biliary cirrhosis is the E2 component of the pyruvate...
Topics
- Autoantibodies
- Bile Ducts
- Cloning, Molecular
- Dihydrolipoyllysine-Residue Acetyltransferase
- Epithelium
- Epitopes
- Female
- Humans
- Immunoglobulin Fab Fragments
- Isomerism
- Liver Cirrhosis, Biliary
- Male
- Mutation
- Pyruvate Dehydrogenase Complex
- Recombinant Proteins