Article
The role of gene mutations in the genesis of familial cancers.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1993
Eng C, Ponder B A
Abstract excerpt
The simplest molecular mechanism of hereditary tumorigenesis is represented by retinoblastoma (RB). Knudson's model specifies that, in hereditary RB, the first mutation in an allele of the RB gene exists in the germline. A subsequent somatic mutation in the second normal RB allele releases RB for...
Topics
- Animals
- Breast Neoplasms
- Carcinoma, Renal Cell
- Colonic Neoplasms
- Humans
- Kidney Neoplasms
- Multiple Endocrine Neoplasia
- Mutation
- Neoplasms
- Neurofibromatoses