Article
Molecular genetics in the pathology and diagnosis of retinoblastoma.
Brain pathology (Zurich, Switzerland) - 1 Sept 1990
Gennett I N, Cavenee W K
Abstract excerpt
Retinoblastoma, the most common intraocular malignancy of children, has served as an important paradigm for understanding the events involved in neoplastic transformation. Much of the contemporary molecular description of human cancers stems directly from experimental approaches first developed to study this childhood tumour. This analytical methodology has demonstrated a major role for heritable predisposition...
Topics
- Cell Transformation, Neoplastic
- Child, Preschool
- Chromosomes, Human, Pair 13
- Eye Neoplasms
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Humans
- Incidence
- Infant
- Infant, Newborn
- Models, Genetic