Pathogenesis of hereditary tumors: beyond the “two‐hit” hypothesis

Abstract excerpt

Knudson's 'two-hit' hypothesis has provided extremely important insights into the pathogenesis of tumors in autosomal dominant tumor predisposition syndromes, but recent evidence suggests that some such tumors may occur without a 'second hit' or require more than two mutations. Inactivation of both RB1 alleles appears to be insufficient by itself to cause malignancy in the tumors that develop in patients with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Histiocytic Disorders and Treatments
• Share to Tuberous Sclerosis Complex Research
• Share to Tumors and Oncological Cases