Article
Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers.
Environmental health perspectives - 1 Nov 1992
Evans H J, Prosser J
Abstract excerpt
A predisposition to the development of certain specific and familial cancers is associated with the inheritance of a single mutated gene. In the best-characterized cases, this primary mutation is a loss of function mutation consistent with viability but resulting in neoplastic change consequent to the acquisition of a second somatic mutation at the same locus. Such genes are referred to as tumor-suppressor genes....
Topics
- Breast Neoplasms
- Child
- Child, Preschool
- Colorectal Neoplasms
- Family
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Humans
- Mutation
- Neoplasms
- Neurofibromatosis 1