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Article

The population genetics of multistage carcinogenesis.

Proceedings. Biological sciences - 7 Jun 2003

Nunney Leonard

Abstract excerpt

Despite the many successes of cancer research, we lack the framework necessary to predict the ratio of familial (inherited) to sporadic (non-inherited) cancers. An evolutionary model of multistage carcinogenesis provides this framework by demonstrating that the number of tumour suppressor loci (TSLs) preventing cancer in a given tissue is expected to depend upon the tissue's vulnerability to pre-reproductive...

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Identifiers

PMID: 12816658
DOI: 10.1098/rspb.2003.2351
PMCID: PMC1691357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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