Article
Genetic predisposition to multiple sclerosis as revealed by immunoprinting.
Annals of neurology - 1 Mar 1997
Epplen C, Jäckel S, Santos E J, D'Souza M, Poehlau D, Dotzauer B, Sindern E, Haupts M, Rüde K P, Weber F, Stöver J, Poser S, Gehler W, Malin J P, Przuntek H, Epplen J T
Abstract excerpt
This study was designed to examine the immunogenetic background predisposing to multiple sclerosis (MS). Three hundred fifty-eight clinically well-characterized MS patients from Germany were investigated and compared to 395 healthy control subjects. Each individual was genotyped for 22 polymorphic markers located within or close to immunorelevant candidate genes including HLA-DRB1*, T-cell receptor (TCR), cell...
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