HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis.

doi:10.1016/0198-8859(91)90073-i

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Article

HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis.

Human immunology - 1 Jan 1991

Spurkland A, Rønningen K S, Vandvik B, Thorsby E, Vartdal F

Abstract excerpt

Serologic DR typing and genomic DRB1, DQA1, DQB1, DPA1, and DPB1 typing using sequence-specific oligonucleotides were performed in 69 multiple sclerosis (MS) patients and 181 healthy controls on in vitro amplified DNA. The frequencies of DR2 as well as the DR2-associated DQA1*0102 and DQB1*0602 a...

Topics

Alleles
Gene Frequency
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR2 Antigen
Haplotypes
Humans
Multiple Sclerosis

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