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Article

Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects.

Neurogenetics - 1 May 1997

Karpuj M V, Steinman L, Oksenberg J R

Abstract excerpt

Several regions of the human genome are associated with susceptibility to multiple sclerosis (MS). We review studies of linkage of MS to germline genes using microsatellites. A modest effect on susceptibility was seen with markers in the vicinity of 6p21 (HLA) and 17q22. The influence of epistatic interactions between these genes is considered. The impact of genetic rearrangements of certain germline genes on...

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PMID: 10735270
DOI: 10.1007/s100480050003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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