Article
Meiotic crossing-over in nondisjoined chromosomes of children with trisomy 21 and a congenital heart defect.
American journal of human genetics - 1 Aug 1993
Howard C M, Davies G E, Farrer M J, Cullen L M, Coleman M M, Williamson R, Wyse R K, Palmer R, Kessling A M
Abstract excerpt
We have used DNA polymorphisms to study meiotic crossovers of chromosome 21q in 27 nuclear families. Each family had a child with Down syndrome and a congenital heart defect. Twenty DNA polymorphisms on chromosome 21 were used to determine parental and meiotic origin of nondisjunction and to iden...
Topics
- Adolescent
- Child
- Child, Preschool
- Chromosomes, Human, Pair 21
- Crossing Over, Genetic
- Down Syndrome
- Fathers
- Female
- Genotype
- Heart Defects, Congenital
- Humans
- Male
- Meiosis
- Mothers
- Nondisjunction, Genetic
- Polymorphism, Restriction Fragment Length