Article
Meiotic crossing-over in nondisjoined chromosomes of children with trisomy 21 and a congenital heart defect.
American journal of human genetics - 1 Aug 1993
Howard C M, Davies G E, Farrer M J, Cullen L M, Coleman M M, Williamson R, Wyse R K, Palmer R, Kessling A M
Abstract excerpt
We have used DNA polymorphisms to study meiotic crossovers of chromosome 21q in 27 nuclear families. Each family had a child with Down syndrome and a congenital heart defect. Twenty DNA polymorphisms on chromosome 21 were used to determine parental and meiotic origin of nondisjunction and to identify crossovers. Twenty-four cases were of maternal origin, and three were of paternal origin. Twenty-two unequivocal...
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