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Article

Elucidating the mechanisms of paternal non-disjunction of chromosome 21 in humans

1 Aug 1998

Abstract excerpt

Paternal non-disjunction of chromosome 21 accounts for 5-10% of Down syndrome cases, therefore, relative to the maternally derived cases, little is known about paternally derived trisomy 21. We present the first analysis of recombination and non-disjunction for a large paternally derived population of free trisomy 21 conceptuses ( n = 67). Unlike maternal cases where the ratio of meiosis I (MI) to meiosis II...

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Identifiers

PMID: 9668162
DOI: 10.1093/hmg/7.8.1221

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