Nondisjunction in trisomy 21: Origin and mechanisms

doi:10.1159/000056844

Article

Nondisjunction in trisomy 21: Origin and mechanisms

1 Jan 2000

Abstract excerpt

Chromosomal aneuploidy is a fundamental characteristic of the human species. In this review we summarize the knowledge about the origin and mechanisms of nondisjunction in human trisomy 21 that has accumulated during the last decade by using DNA polymorphism analysis. The first molecular correlate of nondisjunction in humans is altered recombination, meiosis I errors being associated with reduced recombination...

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