Centromeric genotyping and direct analysis of nondisjunction in humans: Down syndrome.

doi:10.1007/s004120050293

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Article

Centromeric genotyping and direct analysis of nondisjunction in humans: Down syndrome.

Chromosoma - 1 Jun 1998

Shen J J, Sherman S L, Hassold T J

Abstract excerpt

In species with chiasmate meioses, alterations in genetic recombination are an important correlate of nondisjunction. In general, these alterations fall into one of two categories: either homologous chromosomes fail to pair and/or recombine at meiosis I, or they are united by chiasmata that are s...

Topics

Centromere
Chromosomes, Human, Pair 21
Down Syndrome
Electrophoresis, Gel, Pulsed-Field
Family Health
Female
Genetic Markers
Genotype
Humans
Hybrid Cells
Male
Meiosis
Mothers
Nondisjunction, Genetic
Recombination, Genetic
Trisomy

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