Article
Investigation of factors associated with paternal nondisjunction of chromosome 21.
American journal of medical genetics. Part A - 1 Aug 2009
Oliver Tiffany Renee, Bhise Archit, Feingold Eleanor, Tinker Stuart, Masse Nirupama, Sherman Stephanie L
Abstract excerpt
Previous studies on relatively small samples of individuals with trisomy 21 caused by paternally derived errors have shown that: (1) advanced paternal age is not a risk factor for chromosome 21 nondisjunction (NDJ), (2) absence of recombination, but not the location of recombination is associated with paternal NDJ and (3) there is an excess of males among live-births with paternally derived trisomy 21. An excess...
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