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Article

Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. Down Syndrome Collaborative Group.

The New England journal of medicine - 28 Mar 1991

Antonarakis S E

Abstract excerpt

BACKGROUND: Over the past 20 years, the parental origin of the extra chromosome in children with trisomy 21 has been investigated with cytogenetic methods of identifying morphologic variations in chromosome 21. These studies have concluded that the origin of the extra chromosome 21 was maternal in approximately 80 percent of cases and paternal in about 20 percent. METHODS: We studied 200 families, each with a...

Topics

Adult
Alleles
Blotting, Southern
Chromosomes, Human, Pair 21
DNA
Down Syndrome
Female
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1825697
DOI: 10.1056/NEJM199103283241302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1825697-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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