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Article

Risk factors for nondisjunction of trisomy 21

1 Jan 2005

Abstract excerpt

The leading cause of Down syndrome (DS) is nondisjunction of chromosome 21 occurring during the formation of gametes. In this review, we discuss the progress made to identify risk factors associated with this type of chromosome error occurring in oogenesis and spermatogenesis. For errors occurring in oocytes, the primary risk factors are maternal age and altered recombination. We review the current progress made...

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PMID: 16192705
DOI: 10.1159/000086900

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