Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

13 Mar 2008

Abstract excerpt

Nondisjunction of chromosome 21 is the leading cause of Down syndrome. Two risk factors for maternal nondisjunction of chromosome 21 are increased maternal age and altered recombination. In order to provide further insight on mechanisms underlying nondisjunction, we examined the association between these two well established risk factors for chromosome 21 nondisjunction. In our approach, short tandem repeat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18369452
DOI: 10.1371/journal.pgen.1000033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Insights into Human Nondisjunction of Chromosome 21 in OocytesPMID 18369452Read ↗

Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populationsSemantic proximity Read ↗

Nondisjunction in trisomy 21: Origin and mechanismsSemantic proximity Read ↗

Risk factors for nondisjunction of trisomy 21Semantic proximity Read ↗

Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.Semantic proximity Read ↗

A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21.Semantic proximity Read ↗

Non-disjunction of chromosome 21 in maternal meiosis I: evidence for a maternal age-dependent mechanism involving reduced recombinationSemantic proximity Read ↗

Investigation of factors associated with paternal nondisjunction of chromosome 21.Semantic proximity Read ↗

The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte.Semantic proximity Read ↗

An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction.Semantic proximity Read ↗

Elucidating the mechanisms of paternal non-disjunction of chromosome 21 in humansSemantic proximity Read ↗

Down Syndrome: Parental Origin, Recombination, and Maternal AgeSemantic proximity Read ↗

Maternal meiosis II nondisjunction in trisomy 21 is associated with maternal low socioeconomic statusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.