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Article

Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype.

British journal of cancer - 1 Jun 1993

Kamath N, Grabowski D, Ford J, Ganapathi R

Abstract excerpt

Trifluoperazine (TFP) is effective in modulating DNA damage/repair in doxorubicin (DOX) treated cells. In the present study we have characterised the resistance phenotype of parental sensitive L1210 mouse leukaemia cells (L1210/S) adapted to grow in the presence of 0.017 microns DOX+5 microM TFP (L1210/DT). Although with prolonged exposure, 0.017 microM DOX alone produced < 35% cell kill in L1210/S cells, similar...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antineoplastic Combined Chemotherapy Protocols
Calmodulin
Carrier Proteins
Cell Division
DNA Damage
DNA Topoisomerases, Type II
DNA, Neoplasm
Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance

Drug Screening Assays, Antitumor

Etoposide

Leukemia L1210

Membrane Glycoproteins

Mice

Phenotype

Trifluoperazine

Source

Open in PubMed Open full text

Identifiers

PMID: 8099806
DOI: 10.1038/bjc.1993.226
PMCID: PMC1968516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8099806-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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