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Article

Phenotypic and cytogenetic analysis of atypical multidrug resistance in human leukaemic cells selected with methotrexate at high concentration.

Cancer letters - 15 Jun 1990

Kavallaris M, Haber M, Norris M D, Pittman S M, Reed C, Stewart B W

Abstract excerpt

A series of CCRF-CEM sublines selected for extreme resistance to methotrexate has been shown previously to exhibit cross resistance to a number of agents belonging to the multidrug resistance phenotype. The mechanism(s) underlying resistance to vincristine, vinblastine and actinomycin D in the most resistant subline (CEM/MTX R3) has now been investigated. Efflux of [3H]vincristine was more rapid in CEM/MTX R3...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Cell Survival
Dactinomycin
Drug Resistance
Humans
Karyotyping
Leukemia
Membrane Glycoproteins
Methotrexate
Phenotype
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Verapamil

Vinblastine

Vincristine

Source

Identifiers

PMID: 1972035
DOI: 10.1016/0304-3835(90)90102-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1972035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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