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Article

Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells.

Molecular pharmacology - 1 Jan 1991

Ganapathi R, Kuo T, Teeter L, Grabowski D, Ford J

Abstract excerpt

Tumor cell resistance due to enhanced efflux of drugs with diverse structures and/or mechanisms of action is termed multidrug resistance (MDR), and modulation of the MDR phenotype by calcium blockers or calmodulin inhibitors is suggested to involve P-glycoprotein. In drug-sensitive (S) and 5-fold doxorubicin (DOX)-resistant (R0) L1210 mouse leukemia cells, no obvious differences in mdr mRNA or P-glycoprotein...

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PMID: 1670962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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