Article
Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells.
Molecular pharmacology - 1 Jan 1991
Ganapathi R, Kuo T, Teeter L, Grabowski D, Ford J
Abstract excerpt
Tumor cell resistance due to enhanced efflux of drugs with diverse structures and/or mechanisms of action is termed multidrug resistance (MDR), and modulation of the MDR phenotype by calcium blockers or calmodulin inhibitors is suggested to involve P-glycoprotein. In drug-sensitive (S) and 5-fold doxorubicin (DOX)-resistant (R0) L1210 mouse leukemia cells, no obvious differences in mdr mRNA or P-glycoprotein...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Blotting, Southern
- Cell Survival
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance
- Gene Expression
- Leukemia L1210
- Membrane Glycoproteins