Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments.

doi:10.1006/bbrc.1997.6674

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Article

Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments.

Biochemical and biophysical research communications - 29 May 1997

Canitrot Y, Frit P, Salles B

Abstract excerpt

Apoptosis is a major determinant of the effectiveness of antitumor chemotherapy since most of the drugs used in cancer treatment provoke cell death by this process. We selected L1210/0.7R (7-fold) and L1210/3R (16-fold) murine leukemia cells resistant to cisplatin (CDDP) by adaptation of parental...

Topics

Animals
Antineoplastic Agents
Apoptosis
Cisplatin
Drug Resistance, Neoplasm
Genes, bcl-2
Genes, p53
Leukemia L1210
Mice
Phenotype

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