MDL 201,307: a novel benzothiazepine modulator of multiple drug resistance.

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Article

MDL 201,307: a novel benzothiazepine modulator of multiple drug resistance.

Journal of experimental therapeutics & oncology - 1 Mar 1996

Newman R A, Fan D, Munson H R, Martin L A, Ahmed N K

Abstract excerpt

A series of novel benzothiazepine derivatives were evaluated for their relative potential to reverse multiple drug resistance (MDR) phenotype in vitro as well as for their relative cardiovascular activity and neurotoxicity. Compounds were evaluated for antiMDR activity using Chinese hamster ovary...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antibiotics, Antineoplastic
CHO Cells
Cell Division
Cricetinae
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Genes, MDR
Guinea Pigs
Hemodynamics
Humans
In Vitro Techniques
Mice
Phenotype
Rats
Thiazepines

Source

Open in PubMed

Identifiers

PMID: 9414394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9414394-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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