Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain.

Abstract excerpt

We used a "hit and run" gene targeting strategy to generate mice expressing only the p31 isoform of the conserved invariant (Ii) chain associated with major histocompatibility complex (MHC) class II molecules. Spleen cells from these mice appear indistinguishable from wild type with respect to cl...

Topics

• Animals
• Antigen Presentation
• Antigens, Differentiation, B-Lymphocyte
• Base Sequence
• CD4-Positive T-Lymphocytes
• Exons
• Histocompatibility Antigens Class II
• Lymphocyte Activation
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Molecular Sequence Data
• Mutation