Article
Transformation of murine pre-B-lymphocytes by v-erb-B: progression to growth factor independence and tumorigenicity.
Leukemia - 1 Jan 1992
Miller M, Kennewell A, Symonds G
Abstract excerpt
v-erb-B is the principal transforming gene of avian erythroblastosis virus, a replication defective retrovirus that transforms erythroid and fibroblast cells in vitro and causes erythroleukemia and fibrosarcoma in vivo. We have used a recombinant murine retrovirus, based on the truncated genome of Moloney murine leukemia virus and containing a chimeric gag-v-erb-B gene, to determine the murine hematopoietic cells...
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