Article
p53 alteration in gastric precancerous lesions.
The American journal of pathology - 1 Mar 1994
Shiao Y H, Rugge M, Correa P, Lehmann H P, Scheer W D
Abstract excerpt
It has been postulated that chronic atrophic gastritis, intestinal metaplasia, and dysplasia are precancerous stages of stomach tumorigenesis. We investigated the timing of p53 alterations in these events of gastric tumorigenesis. Each of 12 cases of archived tissue containing precancerous and ca...
Topics
- Base Sequence
- DNA
- DNA, Neoplasm
- Gastric Mucosa
- Humans
- Immunohistochemistry
- Lymphocytes
- Metaplasia
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Precancerous Conditions
- Sequence Analysis, DNA
- Stomach
- Stomach Neoplasms
- Tumor Suppressor Protein p53